TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function
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چکیده
منابع مشابه
CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α
BACKGROUND AND AIMS Psychological stress is a predisposing factor in the onset and exacerbation of important gastrointestinal diseases including irritable bowel syndrome (IBS) and the inflammatory bowel diseases (IBD). The pathophysiology of stress-induced intestinal disturbances is known to be mediated by corticotropin releasing factor (CRF) but the precise signaling pathways remain poorly und...
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The intestinal tract is a diverse microenvironment where more than 500 species of bacteria thrive. A single layer of epithelium is all that separates these commensal microorganisms and pathogens from the underlying immune cells, and thus epithelial barrier function is a key component in the arsenal of defense mechanisms required to prevent infection and inflammation. The epithelial barrier cons...
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The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens, and toxins from the gut lumen into the circulation. The equilibrium between the rate of apoptosis and shedding of senescent epithelial cells at t...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2012
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2012.06523.x